Efficacy and Safety of Once-Weekly Thyroxine for Thyroxine-Resistant Hypothyroidism

Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism.

Standard therapy for patients with hypothyroidism is replacement with synthetic thyroxine (T4). However, thyroxine plus triiodothyronine (T3) replacement therapy resulted in marked improvements in several items of the Profile of Mood States and in a few indices of psychometric function and quality of life. The adequacy of thyroxine alone versus thyroxine plus triiodothyronine to treat hypothyro...

Hypothyroidism, thyroxine treatment, and the heart.

Thyroxine-binding prealbumin in thyrotoxicosis and hypothyroidism.

THYROXINE is reversibly bound in the plasma to three proteins: thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin. Changes in the binding capacities of TBG and TBPA in patients with thyroid disease have been reported previously (1, 2). Since starch-gel electrophoresis of serums of patients with thyrotoxicosis indicated a marked decrease in density of the stain in...

Optimisation of thyroxine dose in congenital hypothyroidism.

he introduction of the screening programme for congenital hypo-thyroidism in the late 1970s and early 1980s has been rightly hailed as a major success in the prevention of neurological handicap. With a prevalence of between 1/3000 and 1/5000 live births, congenital hypothyroidism is by far the commonest metabolic disorder leading to neurological handicap; given the inexpensive nature of assays ...

Reappraisal of thyroxine treatment in primary hypothyroidism.

The optimum daily dose of thyroxine was calculated for 13 children aged 3-16 years with primary hypothyroidism by titrating their doses at monthly intervals. The condition of the thyroid was assessed by sensitive assay of thyroid stimulating hormone concentrations, as well as measurement of total and free thyroid hormone concentrations and systolic time interval ratios. Serum thyroid stimulatin...